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cgrp receptor blocker injections  (Boehringer Ingelheim)
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Boehringer Ingelheim cgrp receptor blocker injections
<t>Pharmacological</t> <t>blocking</t> of <t>CGRP</t> or NMDA receptors in the SI-BF or CeA during AIP-induced sleep loss: The experimental protocol for recording sleep with or without AIP and after blocking of either the CGRP (BIBN4096BS; 80µg/ µl) or NMDA (AP-5; 40µg/ µl) receptors with 200nl of antagonists injected bilaterally in either the SI- BF or the CeA using the injectors cannulas and the infusion/withdrawal programmable dual syringe pump ( a ). Photomicrographs of Nissl’s-stained brain sections ( b ) show the guide-cannula tracks used to insert the injector cannulas, whose tips were marked using thionine stain, in the vicinity (within a radius of 1-1.5mm) of the substantia innominata (SI, b1 ) in the basal forebrain (BF) and the central nucleus of the amygdala (CeA, b2 ). Asterisks mark the tip of the injector cannula that extended the guide cannulas by 1 mm, observed either in the same or adjacent section that lie within 1mm of the PBel CGRP terminal sites. Scale in b1 and b2 is 0.5mm. Graphs in c show the percentage (mean ± SEM) of time spent in NREM sleep for each hour ( c1) and in 3h bins ( c2 ) after AIP. The blue rectangle represents the dark phase. The groups were statistically compared using a two-way (treatment X time) ANOVA, followed by Holms-sidak method for multiple comparisons, where **- P<0.001; *- P<0.01. The color of the asterisk compares AIP to the group representing the color in the graph.
Cgrp Receptor Blocker Injections, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Pharmacological blocking of CGRP or NMDA receptors in the SI-BF or CeA during AIP-induced sleep loss: The experimental protocol for recording sleep with or without AIP and after blocking of either the CGRP (BIBN4096BS; 80µg/ µl) or NMDA (AP-5; 40µg/ µl) receptors with 200nl of antagonists injected bilaterally in either the SI- BF or the CeA using the injectors cannulas and the infusion/withdrawal programmable dual syringe pump ( a ). Photomicrographs of Nissl’s-stained brain sections ( b ) show the guide-cannula tracks used to insert the injector cannulas, whose tips were marked using thionine stain, in the vicinity (within a radius of 1-1.5mm) of the substantia innominata (SI, b1 ) in the basal forebrain (BF) and the central nucleus of the amygdala (CeA, b2 ). Asterisks mark the tip of the injector cannula that extended the guide cannulas by 1 mm, observed either in the same or adjacent section that lie within 1mm of the PBel CGRP terminal sites. Scale in b1 and b2 is 0.5mm. Graphs in c show the percentage (mean ± SEM) of time spent in NREM sleep for each hour ( c1) and in 3h bins ( c2 ) after AIP. The blue rectangle represents the dark phase. The groups were statistically compared using a two-way (treatment X time) ANOVA, followed by Holms-sidak method for multiple comparisons, where **- P<0.001; *- P<0.01. The color of the asterisk compares AIP to the group representing the color in the graph.

Journal: bioRxiv

Article Title: Identifying the Brain Circuits that Regulate Pain-Induced Sleep Disturbances

doi: 10.1101/2024.12.20.629596

Figure Lengend Snippet: Pharmacological blocking of CGRP or NMDA receptors in the SI-BF or CeA during AIP-induced sleep loss: The experimental protocol for recording sleep with or without AIP and after blocking of either the CGRP (BIBN4096BS; 80µg/ µl) or NMDA (AP-5; 40µg/ µl) receptors with 200nl of antagonists injected bilaterally in either the SI- BF or the CeA using the injectors cannulas and the infusion/withdrawal programmable dual syringe pump ( a ). Photomicrographs of Nissl’s-stained brain sections ( b ) show the guide-cannula tracks used to insert the injector cannulas, whose tips were marked using thionine stain, in the vicinity (within a radius of 1-1.5mm) of the substantia innominata (SI, b1 ) in the basal forebrain (BF) and the central nucleus of the amygdala (CeA, b2 ). Asterisks mark the tip of the injector cannula that extended the guide cannulas by 1 mm, observed either in the same or adjacent section that lie within 1mm of the PBel CGRP terminal sites. Scale in b1 and b2 is 0.5mm. Graphs in c show the percentage (mean ± SEM) of time spent in NREM sleep for each hour ( c1) and in 3h bins ( c2 ) after AIP. The blue rectangle represents the dark phase. The groups were statistically compared using a two-way (treatment X time) ANOVA, followed by Holms-sidak method for multiple comparisons, where **- P<0.001; *- P<0.01. The color of the asterisk compares AIP to the group representing the color in the graph.

Article Snippet: For the pharmacological blocking, we used CGRP receptor blocker injections, BIBN (BIBN4096BS; 80μg/ml; Boehringer Ingelheim Pharma KG, Biberach, Germany) and NMDA receptor blocker injection, AP-5 (40μg/ml), which were delivered using the injector cannula that was placed in the guide and extending past the tip of the guide by 1mm.

Techniques: Blocking Assay, Injection, Staining